Anti Estrogen Steroids Raws Tamoxifen Citrate

Product Name: Tamoxifen citrate
CAS: 54965-24-1
MF: C32H37NO8
MW: 563.64
EINECS: 259-415-2
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Product Details

Antiestrogen Steroids Tamoxifen Citrate / Nolvadex CAS 54965-24-1

Product Name: Tamoxifen citrate
Synonyms: 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen
CAS: 54965-24-1
MF: C32H37NO8
MW: 563.64
EINECS: 259-415-2


Test Items

Specification

Test Results

Description

White crystalline powder

White crystalline powder

Identification

IR , UV conform

Conform

Loss on drying

≤0.5ml

0.21ml

Residue on ignition

Not more than 0.2%

0.06ml

Iron

Not more than 0.005%

0.0018%

Heavy metals

Not more than 0.001%

0.0006%

Related substances

Total: Not more than 1.0%
Individual: Not more than 0.5%

0.32%
0.14%

E-isomer

Not more than 0.3%

0.19%

Organic volatile impurities

Conforms

Conforms

Assay

99.0~101.0%

99.51%

Conclusion

Conform with USP30



Tamoxifen Citrate Medical uses

1. Breast cancer

Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER)-positive (ER+) breast cancer in pre- and post-menopausal women.[10] Additionally, it is the most common hormone treatment for male breast cancer.[11] It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease.[12] It has been further approved for the reduction of contralateral (in the opposite breast) cancer. The use of tamoxifen is recommended for 10 years.
In 2006, the large STAR clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women taking tamoxifen, although the difference was not statistically significant.
 
2. Infertility

Tamoxifen is used to treat infertility in women with anovulatory disorders. It is given at days 3–7 of a woman's cycle.
Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic-pituitary-adrenal axis (via ER antagonism) and thereby increasing the secretion of luteinizing hormone and follicle-stimulating hormone and increasing testicular testosterone production.
 
3. Gynecomastia

Tamoxifen is used to prevent estrogen-related gynecomastia, resulting from elevated estrogenic levels. It is taken as a preventative measure in small doses, or used at the onset of any symptoms such as nipple soreness or sensitivity. Other drugs are taken for similar purposes such as clomiphene citrate and the anti-aromatase drugs which are used in order to try to avoid the hormone-related adverse effects. Tamoxifen is also sometimes used to treat or prevent gynecomastia in sex offenders undergoing temporary chemical castration.
 
4. Others
Occasionally tamoxifen is used in treatment of the rare conditions of retroperitoneal fibrosis[20] and idiopathic sclerosing mesenteritis.


Tamoxifen Citrate Cook Recipes
50ml @ 20 mg/ml
1 gram of Tamoxifen Citrate
1 beaker suitable for holding the volume of liquids
19.6 ml of Glycerol
29.4 ml of 190 Proof Grain Alcohol
50ml @ 20 mg/ml
1 gram of Tamoxifen Citrate
1 beaker suitable for holding the volume of liquids
9.8 ml of PEG 600
39.2 ml of 190 Proof Grain Alcohol


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