Aromasin Exemestane Anti Estrogen ExeMestine

Quick Details:
​Alias: Aromasin ; Exemestan;ExeMestine
CAS NO: 107868-30-4
MF: C20H24O2
MW: 296.4
Purity: 99%
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Product Details

Aromasin Exemestane Anti Estrogen ExeMestine

Quick Details:
Alias: Aromasin ; Exemestan;ExeMestine
CAS NO: 107868-30-4
MF: C20H24O2
MW: 296.4
Purity: 99%
Appearance: white solid powder.
 
What is Aromasin Exemestan?
Exemestane is an irreversible steroidal aromatase inactivator, the structure of the enzyme natural substrate androst-4-ene-3,17-dione in two similar to the pseudo substrate aromatase, by irreversibly bind to the active site of the enzyme and its inactivation (also known as "the role of self destructive suppression"). From the decreased estrogen levels in postmenopausal women in blood circulation, but the biosynthesis of corticosteroids and aldosterone in the adrenal gland had no obvious effect. In 600 times higher than the concentration of aromatase inhibition, the other steroidogenic enzyme in the pathway is not influenced.
 
High Purity Aromasin / Exemestan
1. High Purity Aromasin/Exemestan/CAS No: 107868-30-4
the third generation aromatase inhibitors, used in the treatment of metastatic breast cancer and used as aid in the treatment of early breast cancer.
2. This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen.


Exemestane Specifications:

TEST ITEMS

SPECIFICATION

RESULTS

Description

White Crystalline Powder

White Powder

Identification

Positive

Positive

Assay(by HPLC)

98.0~102.0%

98.64%

Absorbance(E1cm)

465~495

482.5

Melting Point

191~195°C

193.5~195.0°C

Loss On Drying

0.5%max

0.19%

Specific Rotation

+288°~ +298°

+290.2°

Residue On Ignition

0.1%max

0.03%

Related Substances

Total:1.5%max

<1.3%


Single:0.5%max

<0.4%

Residue Solvents

0.2%max

0.10%

Heavy Metals

20PPm max

<10PPm

Conclusion

The specification conform with enterprise standard.


Exemestane Applications:
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.
In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

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1)Tell the package update ASAP , and will try best solve when customer encountered various problems.
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1) Professional service and rich experience make customers feel comfortable and trust us.
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