Hormonal Steroids Femara for Anti Cancer

Hormonal Steroids Letrozole / Femara CAS 112809-51-5 for Anticancer
Product Name: Letrozole
CAS: 112809-51-5
MF: C17H11N5
MW: 285.3
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Product Details

Hormonal Steroids Letrozole / Femara CAS 112809-51-5 for Anticancer

Product Name: Letrozole
Synonyms: 4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
CAS: 112809-51-5
MF: C17H11N5
MW: 285.3


Letrozole Chemical Properties

Chemical Properties Melting point is 181~183 oC.
Usage Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer.
This information is edited by ChemicalBook Xiao Nan.
Production Method 4-bromine methyl phenyl nitrile and triazole react in chloroform, products and 4-fluorine benzene nitriles react in dimethyl formamide, generate to letrozole in the presence of potassium tert-butyl alcohol.
Chemical Properties white to light yellow crystal
Usage A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic


Tests

Specifications

Results

Appearance

White or off-white crystaline powder

White
Crystalline powder

Solubility

Soluble in ethanol when heated

Conform

ldentification

(1)Maximum absorption in wavelength of 240 nm
Minimum absorption in wavelength of 215 nm

Conform
Conform

(2)Infrared spectrum should be in accordance the dominant peak of contrast

In accordance with the dominant peak of contrast

Melting points

182ºC-184ºC

182ºC

Related substances

≤0.5%

0.3%

Single impurity

≤0.3%

0.2%

Loss on drying

≤1.0%

0.8%

Conclusion

Conforms Specifications of Enterprise Standard.


Letrozole use

This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.


Letrozole doasge

Take letrozole on a regular schedule to get the most benefit from it.
If you miss a dose of letrozole, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use letrozole.


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