Oral Anabolic Steroids Cabergoline for Bodybuilding

CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Chemical Properties White Crystalline Solid
Usage A dopamine D2-receptor agonist.
Usage receptor stimulant
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Product Details

Oral Anabolic Steroids Cabergoline for Bodybuilding

Product Name: Cabergoline
Synonyms: 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide;CABERGOLINE;(8-beta)-(2-propenyl);n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid;FCE-21336,Cabaser,Dostinex;(8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide;Cabaser;Dostine
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Chemical Properties White Crystalline Solid
Usage A dopamine D2-receptor agonist.
Usage receptor stimulant


Cabergoline uses

1. hyperprolactinemia
2. adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas);
3. monotherapy of Parkinson's disease in the early phase;
4. combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease;
5. in some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea);
6. treatment of uterine fibroids.
7. adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing levels and is highly efficient in suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases;
8.and prolactin are similar structurally and have similar effects in many target tissues, therefore targeting prolactin may help symptoms when hormone secretion can not be sufficiently controlled by other methods;
9. Cushing's disease - cabergoline may be used to lower ACTH levels and cause regression of ACTH producing pituitary adenomas;
10. other pituitary adenomas - cabergoline has demonstrated certain efficacy in controlling or reducing other kinds of pituitary adenomas, as well as silent or non-functional adenomas.


Cabergoline Dosage:

Parkinson's disease: Monotherapy: Initial dose should be 0.5 mg daily. The usual maintenance dose is 2 to 4 mg daily. Combination therapy: Usually 2 to 6 mg daily.
Tumors of the pituitary gland and other hyperprolactinemic conditions: Initially 0.5 mg per week, slowly titrated to 4.5 mg per week, if necessary.
Ablactation: According to specific treatment scheme.


ITEM

LIMIT

RESULT

Description

White or almost white crystarlline powder

Conforn

Identify

1. IR complies
2. X-Ray complies
3. HPLC complies

Conforn
Conforn
Conforn

Water

No more than 0.5%

0.2%

Reiated substances

1.Allylamide (USP,rel,D) no more than 0.10%
2. Allyl DHLA(USP,rel,D) no more than 0.15%;
3.Cabergoline oxide no more than 0.10% ;
4.Other impurities individually no more than 0.10% ;
5.Total no more than 0.50% ;

0.02%
Less than 0.02%
Less than 0.02%
Less than 0.02%
0.05%

Assay(HPLC)

98.0-102.0%

100.5%

Opdical rotation

-83.0-- -77.0

-78

Residual Solvents

1.Dichloromethane no more than 100ppm;
2.Acetone no more than200ppm;
3.Tert-butylmethylether no more than 200ppm;
4.Xylene no more than 1500ppm;
5.HEptane no more than 1000ppm;

Less than30ppm
Less than20ppm
Less than10ppm
110ppm
Less than30ppm

Residue on ignition

NO more than0.10 %

0.02%

Heavy metals

NO more than 20ppm

2ppm

Partcle size

90%af particles no mone than 80關m

Conform

Bulk Density

0.2~0.35g/em

0.33g/em

Conclusion

Conforn with EP6.0/ USP38


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