Oral SARMS SR9011 Raw Powder CAS 1379686-29-9 SR-9011 with Fast Delivery
White or off-white powder
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases.
Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.Treatment of diet-induced obese mice with a SR9011 decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia.
An odorless, almost white or white powder
The retention time of the major peak is confirm to the RS
Loss on Drying
Not more than 0.5%
Not less than 99.0%
Not more than 0.1%
Not more than 20 ppm
In vitro: SR9011 was used at 5-10 µM concentration in vitro and in cellular assays.
In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
Increase lean muscle mass
Increase bone density
Can be taken orally
More Detail about SR9011:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV ERB with an EC50 ~790 nM and REV-ERB with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB and REV-ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
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