High quality anticonvulsant drugs powders Carbamazepine CAS 298-46-4
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CAS No.: 298-46-4
Other Names: Carbamazepine-d10
EINECS No.: 206-062-7
Place of Origin: China (Mainland)
Type: Antibiotic and Antimicrobial Agents, Cardiovascular Agents
Grade Standard: Medicine Grade
Purity: Carbamazepine 99.9%
Color: White Powder
What is Carbamazepin?
(1)Carbamazepine (CBZ), is a medication used primarily in the treatment of epilepsy and neuropathic pain.It is not effective for absence seizures or myoclonic seizures. It is used in schizophrenia along with other medications and as a second line agent in bipolar disorder.Carbamazepine appears to work as well as phenytoin and valproate.
(2)Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain;Carbamazepine is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy.;Carbamazepine is also used to treat bipolar disorder.
(1)Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combination with an antipsychotic in some cases of schizophrenia when treatment with a conventional antipsychotic alone has failed. It is not effective for absence seizures or myoclonic seizures.
(2)In the United States, the FDA-approved medical uses are epilepsy (including partial seizures, generalized tonic-clonic seizures and mixed seizures), trigeminal neuralgia, and manic and mixed episodes of bipolar I disorder.
How Dose Carbamazepine works?
The mechanism of action of carbamazepine and its derivatives is relatively well understood.[medical citation needed] Carbamazepine is a use-dependant blocker of voltage-gated sodium channels. It is ionised within intracellular fluid, and is then able to bind to activated voltage-gated sodium channels, preventing repetitive and sustained firing of an action potential.This leaves the affected cells less excitable until the drug dissociates. Carbamazepine is also a GABA receptor agonist, as it has also been shown to potentiate GABA receptors made up of alpha1, beta2, and gamma2 subunits. This mechanism may contribute to its efficacy in neuropathic pain and bipolar disorder. Laboratory research has further demonstrated that carbamazepine is a serotonin releasing agent and possibly even a serotonin reuptake inhibitor.
raw material / china hot selling products/chemical/low price / GMP manufaturer /active pharmaceutical ingredient Carbamazepine:
White or almost white, crystalline powder
very slightly soluble in water ,freely soluble in methylene chloride, sparingly soluble in acetone and in ethanol (96%)
(1) A. Melting Point : 189°C to 193°C
Related substances (BY HPLC)
Impurity A:Not More than 0.1%
Impurity E:Not More than 0.1%
Loss on drying
Assay (on dried substance)
99.0% ~ 102.0%
Conclusion It Conforms to BP2010 standards.
Our Products Rnages:
Anti - inflammatory and hypoglycemic series
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