IGF-1 LR3 CAS 946870-92-4 Polypeptide Hormone 0.1MG 1MG Vials
IGF-1 LR3, 0.1mg
IGF-1 LR3, also known as Long Arg3 IGF-1, is a recombinant protein analogue of human Insulin-Like Growth Factor-1 that has a molar mass of 9,200 Daltons and is comprised of 83 amino acids. IGF-1 LR3 comprises the complete IGF-1 sequence, but with a 13 amino acid extension on the B-Terminus domain and the substitution of an Arginine for the Glutamic Acid at position 3. The LR3 analogue of IGF-1 was created with the intent to drastically increase the biological activity of the protein and IGF-LR3 is several times more potent than rhIGF-1. This specific sequence alteration has decreased the affinity of binding to the IGFBPs, which control the biological actions of IGF-1 and prevent the protein from reaching the IGF-1 receptors.
IGFB Binding and Increased Biological Activity
By resisting IGFBP-binding, IGF-1 LR3 has a greater physiologic effect than IGF-1 does. The longer duration of action allows for smaller amounts to be used with the same effects. Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke. Most studies concerning the effects of IGF-1 derivatives have been carried out in animal models, with little to no data available for humans.
IGF-1 LR3 Applications:
Help regulate fat as energy, resulting in reduced fat.
Help against aging. With age, IGF-1 production slows down, leading to cell reduction. Low levels of IGF-1 are associated with heart failure, brain cell regulation, and neuronal function.
Let alone muscle tissue decomposition.
Helps increase nutrient shuttle (protein synthesis).
Increase the regeneration of nerve tissue function.
Increase the ability of muscle cell proliferation, resulting in more comprehensive muscle tissue.
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